Scientist-Sr Scientist Discovery, Invitro Electrophysiology (Cardiovascular and Neurology)

Bristol-Myers Squibb

  • Princeton, NJ
  • $117,970-142,954 per year
  • Permanent
  • Full-time
  • 8 days ago
Working with Us
Challenging. Meaningful. Life-changing. Those aren’t words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You’ll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams. Take your career farther than you thought possible.Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more: .Overview
We are seeking an experienced and motivated Research Scientist with at least 5 years of laboratory research experience in the pharmaceutical, biotechnology, or academic sectors. The successful candidate will play a key role in our Lawrenceville, NJ Discovery Toxicology team at Bristol Myers Squibb, contributing to early drug discovery through in vitro or ex vivo investigative toxicology studies focused on cardiovascular and nervous system safety assessment, mechanistic investigations, and early biomarker identification.High consideration will be given to candidates with Invitro Electrophysiology and Functional Neuron experience.This position will work within a dynamic, multidisciplinary, matrixed team environment, leveraging advanced cellular models—including stem-cell derived cardiomyocytes and neurons, organoids, and microphysiological systems. Hands-on expertise with functional in vitro assays such as electrophysiology (patch-clamp, multielectrode array), dynamic calcium or fluorescence imaging, and exposure to new approach methodologies is required.The ideal candidate demonstrates a collaborative mindset, rigorous scientific approach, and outstanding communication and technical skills.Key Responsibilities
  • Design, execute, and analyze in vitro studies evaluating cardiovascular or nervous system toxicity for early drug discovery targets and compounds.
  • Develop, optimize, and apply functional assays—electrophysiological, contractility, impedance, imaging, metabolic—using advanced cellular and tissue models for mechanistic safety investigation and biomarker discovery.
  • Characterize on-target or off-target liabilities and pharmacodynamic endpoints in in vitro cellular or ex vivo tissue model systems.
  • Perform multifaceted data analysis using specialized software, including analysis of large data sets and/or use of statistical programming.
  • Author internal scientific reports, prepare manuscripts for publication, and present at internal/external meetings and conferences.
  • Ensure excellent documentation and data recording in compliance with BMS standards and policies.
  • Foster scientific excellence, open communication, and creativity to maximize team productivity.
Required Qualifications
  • PhD+3 years, MA/MS+5 years, BA/BS+7 years research experience (academic, biotech, pharma) in physiology, pharmacology, toxicology, or a closely related field
  • Proven expertise performing and interpreting functional cellular/tissue assays: patch-clamp (manual or automated) electrophsyiology, multielectrode array electrophysiology, contractility, impedance, fluorescence imaging.
  • Practical experience with organoids, microphysiological systems or other new approach methodologies
  • Practical experience with cell culture, including maintenance of cell lines, primary cell isolation and culture, and stem-cell derived models (cardiomyocytes, neurons).
  • Skilled in data analysis, statistics, presentation, and scientific writing.
  • Technically adept, logical, and proactive problem-solver.
  • Effective communicator, capable of collaborating across teams and organizational levels.
Preferred Qualifications
  • Experience in In-Vitro Electrophysiology.
  • Experience in Cardiovascular or Neurology
  • Experience with advanced imaging systems (confocal microscopy, image analysis software).
  • Proficiency in molecular biology techniques: siRNA, PCR.
  • Familiarity with in silico/computational toxicology approaches.
  • Experience with Manual and/or automated patch clamp (e.g. Patchliner, Port -a-Patch).
  • Experience with cell isolation or tissue harvesting for use in functional in vitro/ex vivo assays (electrically excitable cells, smooth muscle, perfused organs).
  • #LI-ONSITE
If you come across a role that intrigues you but doesn’t perfectly line up with your resume, we encourage you to apply anyway. You could be one step away from work that will transform your life and career.Compensation Overview: Princeton - NJ - US: $117,970 - $142,954The starting compensation range(s) for this role are listed above for a full-time employee (FTE) basis. Additional incentive cash and stock opportunities (based on eligibility) may be available. The starting pay rate takes into account characteristics of the job, such as required skills, where the job is performed, the employee’s work schedule, job-related knowledge, and experience. Final, individual compensation will be decided based on demonstrated experience.Eligibility for specific benefits listed on our careers site may vary based on the job and location. For more on benefits, please visitBenefit offerings are subject to the terms and conditions of the applicable plans then in effect and may include the following: Medical, pharmacy, dental and vision care. Wellbeing support such as the BMS Living Life Better program and employee assistance programs (EAP). Financial well-being resources and a 401(K). Financial protection benefits such as short- and long-term disability, life insurance, supplemental health insurance, business travel protection and survivor support. Work-life programs include paid national holidays and optional holidays, Global Shutdown Days between Christmas and New Year’s holiday, up to 120 hours of paid vacation, up to two (2) paid days to volunteer, sick time off, and summer hours flexibility. Parental, caregiver, bereavement, and military leave. Family care services such as adoption and surrogacy reimbursement, fertility/infertility benefits, support for traveling mothers, and child, elder and pet care resources. Other perks like tuition reimbursement and a recognition program.Uniquely Interesting Work, Life-changing Careers
With a single vision as inspiring as “Transforming patients’ lives through science™ ”, every BMS employee plays an integral role in work that goes far beyond ordinary. Each of us is empowered to apply our individual talents and unique perspectives in a supportive culture, promoting global participation in clinical trials, while our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.On-site ProtocolBMS has an occupancy structure that determines where an employee is required to conduct their work. This structure includes site-essential, site-by-design, field-based and remote-by-design jobs. The occupancy type that you are assigned is determined by the nature and responsibilities of your role:Site-essential roles require 100% of shifts onsite at your assigned facility. Site-by-design roles may be eligible for a hybrid work model with at least 50% onsite at your assigned facility. For these roles, onsite presence is considered an essential job function and is critical to collaboration, innovation, productivity, and a positive Company culture. For field-based and remote-by-design roles the ability to physically travel to visit customers, patients or business partners and to attend meetings on behalf of BMS as directed is an essential job function.BMS is dedicated to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace accommodations/adjustments and ongoing support in their roles. Applicants can request a reasonable workplace accommodation/adjustment prior to accepting a job offer. If you require reasonable accommodations/adjustments in completing this application, or in any part of the recruitment process, direct your inquiries to . Visit to access our complete Equal Employment Opportunity statement.BMS cares about your well-being and the well-being of our staff, customers, patients, and communities. As a result, the Company strongly recommends that all employees be fully vaccinated for Covid-19 and keep up to date with Covid-19 boosters.BMS will consider for employment qualified applicants with arrest and conviction records, pursuant to applicable laws in your area.If you live in or expect to work from Los Angeles County if hired for this position, please visit this page for important additional information:Any data processed in connection with role applications will be treated in accordance with applicable data privacy policies and regulations.

Bristol-Myers Squibb