Scientist - Analytical Development

Eli Lilly

  • Boston, MA
  • $69,000-179,300 per year
  • Permanent
  • Full-time
  • 1 day ago
At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world.The Lilly Gene Therapy group is seeking an independent, self-motivated, and highly skilled scientist with a proven track record in designing, developing, and implementing analytical and separation methodologies for the characterization and quality control of mRNA including circular RNA. This is a predominantly lab-based role. The ideal candidate will possess strong expertise in LC, LC-MS, gel and capillary electrophoresis, ELISA and other related skills. The successful candidate will be responsible for method development and routine sample analysis, while providing scientific input to cross-functional teams from the exploratory stage through IND enabling. Additionally, the candidate is expected to explore and evaluate novel analytical and separation techniques to support emerging analytical needs of the team.Responsibilities:
  • Design, develop, optimize, and standardize robust analytical and separation methods—including UPLC, LC-MS, CE, SEC -MALS—for gene therapy, with major focus on mRNA including circular RNA
  • Proactively evaluate and implement innovative analytical technologies to overcome challenges in the analysis of complex systems to continuously promote scientific advancement.
  • Maintain and troubleshoot analytical and separation instrumentation (e.g., UPLC, LC-MS, CE, MALS, etc.) to ensure high performance, reliability, and minimal downtime in support of critical workflows.
  • Continuously refine and improve existing analytical methods and assays and innovate as necessary to meet evolving program needs.
  • Interacts closely with project teams to efficiently implement proper analytical assays through the lifecycle of a project and assist decision-making.
  • Coordinate sample analyses with collaborators both within and outside of Lilly.
  • Maintain thorough, accurate, and timely documentation of experiments, protocols, and results in electronic laboratory notebooks and technical reports.
  • Ensure high standards of laboratory practice, including compliance with safety and quality guidelines, and promote operational excellence in all analytical activities.
  • Communicate findings and progress effectively, including regular presentations in project team meetings.
Basic Qualifications
  • Masters Degree in Analytical Chemistry, Chemistry, Pharmaceutical Sciences or related scientific field with 3+ years of relevant post-graduate work experience. Alternatively, a Bachelors degree in Analytical Chemistry, Chemistry, Pharmaceutical Sciences or related scientific field with 5+ years of relevant post-graduate work experience.
Additional Skills/Preferences:
  • Expertise in mRNA characterization Analytical Method Development and Innovation
  • Proven track record in developing and validating a wide range of analytical and separation techniques, such as LC, LC-MS, ion-pairing LC, SEC, CE, HILIC, HIC, and IEX
  • Instrumentation Proficiency
  • Hands-on experience in the operation, maintenance, and troubleshooting of analytical and separation systems, including UPLC, LC-MS, CE, MALS
  • Experience with preparative systems such as ÄKTA is a plus but not required
  • Familiarity with Agilent, Waters and Thermo platforms and associated softwares (e.g., ChemStation, OpenLab CDS, MassHunter, Xcalibur, Empower, VISION)
  • Knowledge of analytical control strategies and quality standards applicable to early- and late-stage drug discovery Demonstrates a high degree of self-motivation and the ability to work on complex projects with low level of supervision Organizational and Interpersonal Skills
  • Strong written and verbal communication skills with the ability to collaborate effectively across cross-functional teams
  • Detail-oriented, open-minded, and capable of continuous learning in a fast-paced, dynamic environment Proven ability to manage multiple priorities and deliver high-quality results under tight timelines
Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form ( ) for further assistance. Please note this is for individuals to request an accommodation as part of the application process and any other correspondence will not receive a response.Lilly is proud to be an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status.Our employee resource groups (ERGs) offer strong support networks for their members and are open to all employees. Our current groups include: Africa, Middle East, Central Asia Network, Black Employees at Lilly, Chinese Culture Network, Japanese International Leadership Network (JILN), Lilly India Network, Organization of Latinx at Lilly (OLA), PRIDE (LGBTQ+ Allies), Veterans Leadership Network (VLN), Women’s Initiative for Leading at Lilly (WILL), enAble (for people with disabilities). Learn more about all of our groups.Actual compensation will depend on a candidate’s education, experience, skills, and geographic location. The anticipated wage for this position is $69,000 - $179,300Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities).Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lilly’s compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees.#WeAreLilly

Eli Lilly