Senior Director, Research Informatics & Automation

LifeMine Therapeutics

  • Cambridge, MA
  • Permanent
  • Full-time
  • 18 days ago
LifeMine Therapeutics is seeking an experienced, highly motivated, and versatile leader to manage a unified Research Informatics and Automation team. The Senior Director will establish the strategic vision across both areas of focus and lead a team that delivers world-class, right-sized solutions to partners across R&D drug discovery and clinical development to empower and transform scientific operations. This pivotal role combines the cutting-edge realms of automation with informatics, requiring a leader who has not only directed high performing teams in deploying high-throughput automated workflows but also one who has overseen the strategic implementation of informatics solutions to bolster scientific operations.As a key member of the R&D team, the ideal candidate is experienced in supporting and enabling research teams, has a deep understanding and grasp of the business and scientific context, and has a demonstrated track record of delivering complex informatics solutions that combine data/instrument/sample management and data/system integrity. The Senior Director must excel at bridging the gap between technology and practical application, ensuring LifeMine's R&D initiatives are not only scientifically sound but also aligned with overarching business objectives.Job Responsibilities
  • Lead the development and execution of advanced Automation and Research Informatics strategies to enhance lab efficiency and scientific discovery.
  • Develop and maintain strategic roadmaps for all relevant scientific data management, inventory management, scientific operation workflow tools, and their integration.
  • Develop and maintain R&D policies for system access and usage, particularly regarding data capture and ELN compliance.
  • Work closely with discovery teams and data scientists for support and continued improvement of discovery informatics solutions including LIMS, data warehouse, workflow management, and data/system integration.
  • Design automated workflow solutions including equipment considerations, space and layout, add-ons and automated accessories, consumables and data management solutions.
  • Champion the deep integration between data generation from automation and data capture/analysis from research informatics, facilitating a seamless flow of critical information for scientific advancements.
  • Manage the integration and application of automation technologies, including robotics and high-throughput bioassays, to enhance research throughput and quality.
Job Requirements
  • Ph.D. in Informatics, Computer Science, Engineering, or a relevant scientific field
  • Training in computer science and software development is highly desirable
  • 10+ years in the biopharmaceutical industry directly supporting discovery and development is a must, with a proven track record in lab automation, screening, and informatics that directly support discovery and clinical development
  • Experience in integrating and automating in vitro and NGS assays, with a working knowledge of complex biological models for HTS applications. Experience in analytical and metabolomic workflow is a plus.
  • Demonstrated leadership experience leading enterprise solutions and a team in a multi-disciplinary R&D setting. Experience with LIMS, scientific data management, compound management, sample inventory, instrument data capture, assay results, and electronic laboratory notebooks is a must-have.
  • Deep understanding of automation technologies for both biochemical and cell-based assays, including proficiency with Tecan, Hamilton, Agilent robots and high content screening assays
  • Solid programming skills in Python and SQL with familiarity with DoE models and relevant software for assay development; experience with Nextflow and end-user web application development is a plus.
  • Experience supporting clinical development team is a plus.
  • Experience with cloud technology integration, processes, and security good practices (AWS-focused)
  • Familiarity with high performance cloud computing
  • Experience with end-user web-application development
  • Demonstrated ability to communicate with and build strong working relationships with diverse business partners, including senior executives
  • Extremely curious and intellectually capable of developing an understanding of business and scientific contexts
LifeMine is an Equal Opportunity Employer and Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sexual orientation, gender identity, age, physical or mental disability, veteran status, genetic information, ethnicity, citizenship, or any other characteristic protected by law.We kindly request no solicitations by agencies or firms regarding this role.

LifeMine Therapeutics