Scientist I/II, LNP
CRISPR Therapeutics
- Boston, MA
- Permanent
- Full-time
The candidate will be leading our efforts in the design and execution of novel and existing lipid nanoparticle (LNP) formulations to help advance our non-viral delivery platform and take next-gen editing modalities for bespoke indications from concept to clinical application. We are searching for a driven, enthusiastic, and self-motivated individual who is comfortable multitasking and working independently as well as part of a larger team on various aspects of in-vivo delivery. This individual will join the dynamic, rapidly growing, and highly collaborative CRISPR-X division.Responsibilities
- Design, optimize, and execute LNP formulations for a variety of compositions and payloads with minimal supervision
- Determine key formulation parameters to provide reproducible and effective LNPs.
- Lead the production and characterization of LNPs for various studies enabling a clinical applications.
- Work collaboratively with scientists across the organization to advance company goals and enhance the understanding of LNP function.
- Be highly organized and meticulous in documenting results in electronic lab notebooks, and present findings to the broader team.
- Effectively multitask and manage multiple projects simultaneously.
- Stay up to date on in-vivo delivery literature and industrial practice.
- Ph.D. in Bioengineering, Chemical Engineering, Biochemistry, Organic Chemistry, or related field and
- Scientist I: 0-2 years of relevant experience
- Scientist II: 2-5+ years of relevant experience
- Extensive hands-on experience and deep expertise in formulating LNPs for gene editing applications in human health.
- Hands on experience with HPLC, DLS, Ribogreen, TEM and other analytical methods.
- Pays great attention to details in the quality and reproducibility of the LNPs
- Strong communication and troubleshooting skills.
- A team player with strong interpersonal skills, and ability to collaborate effectively with others.
- Prior experience in LNP conjugation chemistries for drug delivery
- Prior experience in using LNPs in mammalian cell culture and animal models.
- Collaborative – Openness, One Team
- Undaunted – Fearless, Can-do attitude
- Results Orientation – Delivering progress toward our mission. Sense of urgency in solving problems.
- Entrepreneurial Spirit – Proactive. Ownership mindset.