Predictive BioProcess Simulation for Cost & Design

Sartorius

  • Marlborough, MA
  • Permanent
  • Full-time
  • 2 months ago
As a Predictive Process Cost Analysis and Design Expert, you will be instrumental in addressing both immediate and long-term challenges in bringing novel therapeutics to patients. Your role is crucial in bridging the gap between drug discovery and biomanufacturing, by using process economics and sustainability tools to identify key bioprocessing challenges to be conquered by feasibility studies.Sartorius is one of the world‘s leading technology providers to the life sciences and biopharma industries, and is actively shaping dynamic, innovative and high-growth markets. To drive the creation of new innovative solutions, Sartorius has formed an initiative to discover new trends and cutting-edge opportunities for rapid conversion towards next generation technology solutions. This exciting initiative in Sartorius Corporate Research is at the forefront of developing next-generation bioprocesses and biomanufacturing technologies. We specialize in a range of novel therapeutic modalities, including monoclonal antibodies (mAbs), induced pluripotent stem cells (iPSC), viral vectors, and mRNA therapies.Role Overview:As a Predictive Process Cost Analysis and Design Expert, you will be instrumental in addressing both immediate and long-term challenges in bringing novel therapeutics to patients. Your role is crucial in bridging the gap between drug discovery and biomanufacturing, by using process economics and sustainability tools to identify key bioprocessing challenges to be conquered by feasibility studies. Disruptive technologies to revolutionize the industry and will be designed, developed and assessed both by simulation tools and prototype evaluations.This pioneering approach will bridge the integration of process cost analysis, with the latest rapid computational fluid dynamics methodologies. This will provide improved technology design and prediction of operating conditions to streamline process development. The role will be foundational to driving direction and focus for identifying & handling of the key challenges facing the bioprocessing of new and novel modalities.What you will accomplish together with us
  • Drive the process cost modeling and simulation strategy.
  • Create & execute process cost analysis models for next generation bioprocessing.
  • Processing for next generation intensified mAbs as well as gene therapy, cell therapy and cell free manufacturing. The work will play a vital role in directly focused research to the key bottle necks and the cost targets that should be achieved.
  • Designing and implementing the process design for sustainability’ where process analysis for cost will be optimized alongside sustainability process targets to minimize waste, reduce water and drive circularity economy of plastics.
  • Integrate hands-on bioprocessing knowledge with novel GPU accelerated computational fluid dynamics (CFD) simulations to rapidly design and develop new technologies (e.g., bioreactors, media exchange, cell separation units) addressing current limitations in biomanufacturing of advanced therapies (AT).
  • Collaborate with data analytics experts and identify innovative approaches to incorporating process cost and sustainability analysis into process simulations as process development optimizer and guided decision-making tools of the future.
  • Support collaborations within Corporate research and across Sartorius in technology assessment leading to new business opportunities.
What will convince us
  • Masters or PhD in biomedical, chemical, or biochemical engineering or related field with 5-10 years industry experience
  • A track record of process cost modeling and simulations of mAbs and preferably viral processing and cell therapy using different methods and tools including such as Biopharma Services Biosolve Process cost analysis tool
  • Having an overview about the different cost methods in the scientific and industrial community and analytical cost analysis and modeling tools available
  • Recognized experience of applying process cost analysis to drive and influence R&D strategies
  • Experience in process simulation and predictive control tools
  • Strong desire to work on multidisciplinary projects working alongside data analysts, bioprocess engineers and biologists.
  • Ability to prioritize tasks and balance individual technical contribution with coordination of fast paced research activities across multiple sites, organizations, and disciplines.
  • Capability to network and communicate within Sartorius, the scientific community and with external experts and customers
  • Operatively oriented, proactive in finding solutions and positive mindset
  • Identification with our core values: Sustainability, Openness, Enjoyment
What We OfferAs a growing global life science company, with our stock listed on the German DAX and TecDAX , Sartorius offers a wide range of benefits:
Personal and Professional Development: Mentoring, leadership programs, internal seminar offerings
Worklife Balance: Paid vacation, sick time, corporate holidays and community service day; as well as flexible work schedules
Making an Impact Right from the Start: Comprehensive onboarding, including a virtual online platform
Welcoming Culture: Mutual support, team spirit and international collaboration; communities on numerous topics such as “Coaching”, “Agile Working” and a “Businesswomen’s Network”
Health & Well Being: Wide selection of health and well-being support such as a variety of medical plans to choose from, dental, vision, EAP, and other wellness programs.
Intelligent Working Environment: Working in smart buildings with the latest technology and equipment.Retirement Savings Plan: 401 k (with generous company match)
Flexible Spending: HSA, FSA (dependent care & healthcare spending), Transportation Commuter Account
Company Paid Benefits: Basic Life Insurance, AD&D, EAP, Family Planning & Women’s Health, Health Advocate
Additional/Optional: Supplemental Life Insurance (employee, spouse & dependents), Legal Services, LTD & STD, Critical Illness Insurance, Student Loan Tuition Refinance ServiceSartorius is an equal opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, national origin, age, protected veteran status, disability or based on status in any other protected group of class.Please view equal employment opportunity posters provided by OFCCPFor Residents of California please review;#LI-remoteSartorius is part of the solution in the fight against cancer, dementia, and many other diseases. Our technologies help translate scientific discoveries into real-world medicine faster, so that new therapeutics can reach patients worldwide. We look for ambitious team players and creative minds, who want to contribute to this goal and advance their careers in a dynamic global environment. Join our global team and become part of the solution. We are looking forward to receiving your application.We look forward to receiving your application.If you are a qualified individual with a disability or a disabled veteran and are unable or limited in your ability to use or access our website, you may request a reasonable accommodation to express interest in a specific opening. You can request reasonable accommodation by e-mail atSartorius is an equal opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, national origin, age, protected veteran status, or disability, or based on status in any other protected group of class.If you are a qualified individual with a disability or a disabled veteran and are unable or limited in your ability to use or access our website, you may request a reasonable accommodation to express interest in a specific opening. You can request reasonable accommodation by e-mail at accommodationrequest@sartorius.comAbout SartoriusSartorius is part of the solution in the fight against cancer, dementia, and many other diseases. Our technologies help translate scientific discoveries into real-world medicine faster, so that new therapeutics can reach patients worldwide.We look for ambitious team players and creative minds, who want to contribute to this goal and advance their careers in a dynamic global environment.Join our global team and become part of the solution. We are looking forward to receiving your application.

Sartorius