Senior Scientist, In Vivo Pharmacology, Oncology Research
AstraZeneca
- Gaithersburg, MD
- Permanent
- Full-time
- MS (
- Experience developing and working with complex in vivo models, such as xenograft, patient derived xenograft (PDX), syngeneic and autochthonous mouse models.
- Experience delivering in vivo pharmacology studies in mouse tumor models, including dose-finding tolerability studies, PK/PD and efficacy studies.
- Experience with a range of in vitro skills, e.g. cell culture, molecular biology, immunoblotting, flow cytometry and ELISA.
- Works independently, assesses and reports data in a clear and concise manner, with a clear understanding of its implications within the overall context of drug discovery.
- Maintains a well-developed understanding of approaches to drug discovery and applies a broader functional knowledge of the procedures used by diverse project groups to support the department where needed.
- Strong interpersonal and collaboration skills together with evidence of delivery in a team-oriented, collaborative environment.
- A proven track record of high productivity and scientific publications in peer reviewed journals.
- Experience with orthotopic xenograft and humanized models of cancer.
- Experience using biologics including, peptides, antibodies, antibody-drug conjugates and oncolytic viruses.
- Experience designing, conducting and analyzing multi-spectral flow cytometry immune-phenotyping studies.
- Knowledge of the Industrial drug discovery process.