Sr Research Associate, In Vivo Pharmacology
Alexion Pharmaceuticals
- Lexington, MA
- Permanent
- Full-time
- Develop and characterize various mouse models
- Perform PD/efficacy studies to support preclinical development of gene therapy candidates
- Perform in vitro, in vivo and ex vivo studies to understand the mechanisms of action of therapeutics
- Prepare, review and deliver scientific findings for internal/external use
- Keep accurate records of research activities and experimental details
- Compliance to animal use policy of welfare and handling
- BS/MS in pharmacology, biology or related disciplines
- ≥ 3 years of experience in executing preclinical in vivo studies using mouse models
- Highly skilled in animal colony management, general animal handling, compound dosing (IV, PO, IP and SC), blood collection (tail vein, submandibular/submental), euthanasia and necropsy (tissue collection and processing)
- Experienced in tissue sample processing for molecular biology biomarkers such as DNA, RNA extraction
- Experience in performing protein assays such as ELISA and enzyme activity is a plus
- Experience in AAV gene therapy and genetic mouse models is strongly desired
- Proficiency in basic software (e.g. MS office) and strong data analysis skills
- Excellent interpersonal and collaborative skills, and the ability to work both independently and as part of team
- Proven ability of multi-tasking, strong analytical and problem-solving skills
- Flexibility and aptitude for learning with a passion to drive cutting-edge science
- Application of creativity and problem-solving skills for model and assay development
- Strong ability to work with others in a matrixed team environment
- Candidate must possess critical time-management skills to creatively accomplish challenging tasks in a timely manner
- A positive “can-do” mindset
- The duties of this role are conducted in an office environment. As is typical of an office-based role, employees must be able, with or without an accommodation to use a computer; engage in communications via phone, video, and electronic messaging; engage in problem solving and non-linear thought, analysis, and dialogue; collaborate with others; maintain general availability during standard business hours.