Principal Scientist, Drug Product Development

Foghorn Therapeutics

  • Cambridge, MA
  • Permanent
  • Full-time
  • 10 days ago
  • Apply easily
Our Culture: Why work with us?At Foghorn Therapeutics, we believe in “People First, Mission Always.”We put “People First” because we know our people are the key to everything we will accomplish. We value the diversity of background, ideas, perspectives and experiences that our team members bring to Foghorn Therapeutics – demonstrated by our community speaking more than 22 languages and representing over 24 nationalities. We value our teammates as people, not just as employees – validated by our actions that let our people know that we care about them, their families, and their lives.We say “Mission Always” because we know a relentless commitment to our mission will make a difference in the lives of others. We believe our success will come from evaluating the data to follow the science. We work hard to develop a new class of therapies that could improve the lives of over 2.5 million people with cancer.Our culture is focused on succeeding through the evaluation of data, not people. And in that, relationships can flourish and develop.Our Science:The groundbreaking science behind our therapies continues to yield vital insights into diseases that have confounded physicians and researchers. Our core scientific approach is centered on the chromatin regulatory system, which opens and closes the right sections of DNA at the right time. Breakdowns in the chromatin regulatory system lead to a wide range of diseases, including cancer, impacting millions of people.Our proprietary Gene Traffic Control® platform is a powerful tool for understanding and modulating the chromatin regulatory system. We are pursuing multiple treatments for breakdowns in this system. We are the only company with the ability to study and target the chromatin regulatory system at scale, in context, and in an integrated way.Job SummaryFoghorn Therapeutics is seeking a motivated Principal Scientist to join the drug product development group within Chemistry Manufacturing and Controls (CMC) to pursue an exciting role in cutting-edge formulation development and drug delivery technologies to support our portfolio. The individual will be responsible to take a leadership role in development of specialty drug delivery technologies and will be responsible to lead and execute the assessments of various innovative drug delivery technologies for development of complex injectables and solid oral dosage forms to support Foghorn’s portfolio at both preclinical and clinical stages. Based on experience level, the candidate will lead the CMC laboratory activities in-house and/ or also represent their function in program/ project teams allowing opportunities for cross-functional involvement/ collaboration. The candidate will also eventually support clinical formulation development and manufacture at CDMOs and regulatory filings.RequirementsRequirementsMinimum Qualifications
  • PhD in chemical engineering, pharmaceutics, chemistry, material science or related field
  • 5+ years of industry experience in drug delivery areas or formulation/drug delivery experience in the pharmaceutical industry for Sr. Scientist.
  • Experience in LAI (long-acting injectables)
Preferred Qualifications and Role Expectations
  • Prior experience and a good understanding of one or more long acting or targeted drug delivery technologies such as nanosuspensions, liposomes, PLGA microspheres technology are preferred.
  • Excellent scientific knowledge in formulation technologies, material science, chemistry, preformulation and formulation sciences – experience / exposure in drug delivery, complex / long acting parenterals, modified release formulation platforms are a significant plus and will be preferred
  • Laboratory based skills including various drug delivery platforms, analytical characterization is a must.
  • Ability to learn rapidly, have a flexible mindset and to be able to adapt to fast paced highly matrixed environments
  • Effective verbal and written communication skills
  • A desire to be part of a highly innovative company aimed at helping patients with serious diseases
BenefitsFoghorn Therapeutics is pleased to provide you and your family with a comprehensive suite of benefits, including:
  • Highly competitive and inclusive medical, dental and vision coverage options
  • BCBS PPO and PPO HSA plans
  • BCBS Dental Plan
  • EyeMed Vision Plan
  • FSA and HSA for medical expenses and dependent care expenses
  • 401(k) Program via Fidelity with the company match
  • Corporate Wellness Program
  • Unlimited Paid Time Off policy
  • Winter shut down
  • 12 weeks of 100% paid parental leave for birthing/primary parent and primary guardian in case of adoption and 3 weeks of 100% paid parental leave for non-birthing/non-primary parent/guardian.
  • Paid Life, LTD and STD insurance coverages, as well as voluntary benefit options
  • Free parking, subsidized commuter passes, or a $100 monthly stipend for walking/biking to work
  • Company lunches on Wednesdays
Foghorn Therapeutics is a smoke-free, alcohol-free and drug-free work environment.Foghorn is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person’s race, color, gender, age, religion, national origin, ancestry, disability, veteran status, genetic information, sexual orientation or any characteristic protected under applicable law. Foghorn Therapeutics will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

Foghorn Therapeutics