Scientist I, Vector Analytics
Alexion Pharmaceuticals
- Durham, NC
- Permanent
- Full-time
- Titering rAAV by multiple methods (ddPCR, qPCR, etc)
- Evaluation of packaged genome (electrophoresis and sequencing-based)
- Assessing overall purity (CE-SDS, qPCR, ELISA, etc)
- Sequence analysis and sample prep for NGS
- Writing reports, SOPs, and generating CoAs. Accurate and detailed documentation of sample records is critical using systems such as electronic lab notebooks.
- General laboratory operations - Maintaining inventories, monitoring/calibrating/cleaning equipment and checking stocks of required consumables.
- Sharing data/results in group settings and larger organizational meetings
- Evaluating new methodologies and staying well-versed with cutting edge methods
- Bachelor or above in Biology or related science discipline (at least 2 years with Bachelor or 0-1 year with Masters)
- Proficient with standard AAV analytical assays: ddPCR, qPCR, DNA content assessment, ce-SDS, ELISA, etc.
- Experience with sample prep for NGS and/or an aptitude for general sequence analysis
- Excellent research task oversight skills including adherence to procedures, best practices and detailed documentation/record keeping
- Superior organizational and time management skills, ability to prioritize multiple demands and work efficiently under pressure
- Excellent oral and written communication skills
- Demonstrated ability to utilize standard office software (Excel, PowerPoint, Word, etc.) or other Project Management/eNotebooks software
- The duties of this role are generally conducted in an lab environment. As is typical of a lab-based role, employees must be able, with or without an accommodation to: lift/carry 15/30 pounds unassisted/assisted; work comfortably in a controlled environment with and around biological, infectious, and hazardous materials; gown/degown PPE; use a computer; engage in communications via phone, video, and electronic messaging; engage in problem solving and non-linear thought, analysis, and dialogue; collaborate with others; maintain general availability during standard business hours.
- NGS analysis skills
- Experience with cell potency assay development and evaluation
- Experience with analytics relating to plasmid DNA quality
When we put unexpected teams in the same room, we unleash bold thinking with the power to inspire life-changing medicines. In-person working give us the platform we need to connect, work at pace and challenge perceptions. That's why we work, on average, a minimum of four days per week from the office. But that doesn't mean we're not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world.AstraZeneca requires all US employees to be fully vaccinated for COVID-19 but will consider requests for reasonable accommodations as required by applicable law.AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.